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KMID : 0931320120120030133
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대한상부위장관.헬리코박터학회지
2012 Volume.12 No. 3 p.133 ~ p.140
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Epidemiology of Adenocarcinoma of Esophagogastric Junction
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Hong Jin-Hon
Kim Hyun-Soo
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Abstract
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The incidence of adenocarcinoma of esophagogastric junction (AEG) has increased rapidly over the past three decades in Western countries, but data from Asian populations are conflicting. The most commonly used classification is that described by Siewert and Stein, which defines AEG as tumors that have their center within 5 cm proximal or distal to the anatomic cardia. However, there is lack of consensus in definition and classification of AEG, which has resulted in difficulties in comparing the various studies on the epidemiology of AEG. The cause of changing pattern of AEG is not clear. Known risk factors for AEG are Barrett’s esophagus, gastroesophageal reflux, obesity, smoking, and medications that relax the lower esophageal sphincter. On the other hand, non-steroidal anti-inflammatory drugs (NSAIDs), Helicobacter pylori infection, fruits and vegetables, and antioxidants might reduce the risk. Currently, there is no evidence that strongly supports any strategy for surveillance of population at high risk of AEG. In Asian countries, the incidence of AEG still low, however, some countries report the increasing trend of adenocarcinoma of lower esophagus and cardia.
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KEYWORD
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Epidemiology, Adenocarcinoma of esophagogastric junction, Helicobacter pylori
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